Head back to its Settings and go to the Storage section. Start VirtualBox, select the virtual machine where you want to run your 64-Bit OS and go into the settings of this VM. If you see the expression “Invalid settings detected” at the bottom of the screen, hover the mouse over it to see what settings need to be adjusted. Invalid settings detected virtualbox system acceleration mac VirtualBox Mac USB devices can “pass through” a Mac operating system and- instead- function on the virtual machine running Windows OS.